BETA GLUCAN, TRITERPEN EXTRACT FROM REISHI MUSHROOM SUPPORTING TUMOR (1).
BETA GLUCAN, TRITERPEN EXTRACT FROM REISHI MUSHROOM SUPPORTING CANCER CELSS (2).
The five mechanisms of action on cancer cells of Triterpene – Linh Chi
Triterpenes – Ganoderma lucidum has been shown to induce cyclic arrest in phase G1 by downregulating Cyclin D1, and in phase G2 by blocking PKC activity. Triterpene also promotes apoptosis in cancer cell lines through a mitochondrial-dependent pathway followed by activation of caspase cascade. Triterpenes also suppressed tumor metastasis by modulating MMP and IL-8 and inhibiting inflammatory cytokine secretion in macrophage cells. Ultimately, triterpenes were found to act as an antioxidant by removing free radicals and enhancing innate antioxidant enzymes.
Three mechanisms of action on cancer cells of Betaglucan – Linh Chi
Betaglucan – Ganoderma lucidum has been shown to enhance immune response by stimulating the production of macrophages, NK cells and T lymphocytes. Like triterpenes, betaglucan can act as an antioxidant by reducing Oxidative damage caused by ROS and prevents DNA strand breakage. Betaglucan – Ganoderma lucidum also prevents tumor angiogenesis by reducing the proliferation of HUVEC and by inhibiting the secretion of vascular factors such as VEGF and TGF-β1.
Thus, Betaglucan Triterpen (Ganoderma lucidum) effectively supports chemotherapy cancer patients with the following benefits:
Increased response, decreased tumor size when used in combination with chemotherapy
Supports action on cancer cells with the following mechanisms:(1) Prevent the reproductive cycle, the cell division cycle of cancer cells(2) Prevent-reduce metastasis thanks to leukocytosis, support to destroy single cancer cells(3) Restriction of angiotensis progression – excessive vascular formation in cancer cells(4) Promote apotosis – programmed cell death cycle.
The most optimal benefit for cancer patients is Betaglucan Triterpene 1-2 days before chemotherapy.
(2) Kao, C., Jesuthasan, A. C., Bishop, K. S., Glucina, M. P., & Ferguson, L. R. (2013). Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways. Functional Foods in Health and Disease, 3(2), 48-65.
(3) Calviño, E., Pajuelo, L., de Eribe Casas, J. A. O., Manjón, J. L., Tejedor, M. C., Herráez, A., … & Diez, J. C. (2011). Cytotoxic action of Ganoderma lucidum on interleukin‐3 dependent lymphoma DA‐1 cells: involvement of apoptosis proteins. Phytotherapy Research, 25(1), 25-32.